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prograf should not be used simultaneously with cyclosporine see dosage and administration .

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reduce prograf dose for voriconazole and posaconazole, give one-third of the original dose and adjust dose based on prograf whole blood trough concentrations.

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two open-label, randomized, comparative trials evaluated the safety and efficacy of prograf-based and cyclosporine-based immunosuppression in primary orthotopic heart transplantation.

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it is recommended that prograf be used concomitantly with azathioprine or mycophenolate mofetil mmf and adrenal corticosteroids see clinical studies 14.

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